| Autor: |
Haofei Shen, Min Gao, Qiuyuan Li, Huipeng Sun, Yingdi Jiang, Lihong Liu, Jingyuan Wu, Xiao Yu, Tianyu Jia, Yongan Xin, Shiqiang Han, Yiqing Wang, Xuehong Zhang |
| Rok vydání: |
2022 |
| DOI: |
10.21203/rs.3.rs-2228346/v1 |
| Popis: |
Owing to its difficulty in degrading and ease of accumulation in the body, perfluorooctanoic acid (PFOA) has a detrimental effect on reproduction. This study aimed to examine the effect of PFOA concentration in follicular fluid during ovulation stimulation on embryo quality and the impact of PFOA exposure on the metabolic components of follicular fluid. This was a single-center prospective study that included 25 patients with diminished ovarian reserve (DOR), 25 with normal ovarian reserve (NOR), and 25 with polycystic ovary syndrome (PCOS). Follicular fluid samples were analyzed using ultra-high performance liquid chromatography-tandem mass spectrometry. We demonstrated that the PFOA levels of follicular fluid in the DOR group were higher than those in the NOR group and PCOS group (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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