Metabolismo mineral en niños en diálisis peritoneal crónica
| Autor: | Francisca Ugarte P, Francisco Cano Sch, Iris Delgado B, Angela Delucchi B, Lily Quiroz Z, María José Ibacache M, Carlos Irarrázabal M, María Luisa Ceballos O, Marta Azócar P, Angélica Rojo L |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Nephrology
medicine.medical_specialty business.industry medicine.medical_treatment Renal function urologic and male genital diseases medicine.disease Left ventricular hypertrophy Gastroenterology female genital diseases and pregnancy complications Peritoneal dialysis Internal medicine Pediatrics Perinatology and Child Health medicine Vitamin D and neurology business Klotho Dialysis Kidney disease |
| Zdroj: | Revista chilena de pediatría. 85:31-39 |
| ISSN: | 0370-4106 |
| Popis: | Introduction: Children with chronic kidney disease (CKD) and receiving peritoneal dialysis (PD) have disorders of mineral metabolism that impact their growth, survival and cardiovascular functions. New molecular markers offer a better understanding of the pathophysiology of this disease. Objective: To characterize some components of mineral metabolism, with emphasis on FGF23/Klotho and cardiovascular functions (CV) of these patients. Patients and Method: Prospective observational cohort study. Exclusion criteria: serum 25 (OH) vitamin D 38 g/m 2 was confirmed in 20/28 patients. Conclusions: The values of FGF23, and PTH are elevated in children with CKD on PD. Klotho levels in CKD patients are lower than control children. A strong association of calcemia with FGF23 and PTH is reported. Residual renal function is inversely associated with FGF23 and Klotho. A high incidence of left ventricular hypertrophy was found evidencing a cardiovascular compromise in these patients. |
| Databáze: | OpenAIRE |
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