Design, synthesis and anti-mycobacterial evaluation of imidazo[1,2-a]pyridine analogues
| Autor: | Yogesh Mahadu Khetmalis, Surendar Chitti, Anjani Umarani Wunnava, Banoth Karan Kumar, Muthyala Murali Krishna Kumar, Sankaranarayanan Murugesan, Kondapalli Venkata Gowri Chandra Sekhar |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | RSC Medicinal Chemistry. 13:327-342 |
| ISSN: | 2632-8682 |
| Popis: | 34 imidazo[1,2-a]pyridine amides & sulfonamides are synthesized & evaluated for in vitro anti-TB activity against MTB H37Rv. IPA-6 is most potent with MIC 0.05 μg mL−1 & 125 times active than ethambutol & docked to MTB enoyl acyl protein reductase. |
| Databáze: | OpenAIRE |
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