Anti-anaemic effect of ethanol leaf extract of Cnidosculus aconitifolius on cyclophosphomide-induced anaemia in rats
| Autor: | Taiwo Oluwaseun Ayoola, Aishat O. Olatunji, K. T. Biobaku, J.A. Atata, Abdullateef Ajadi, Sani Adamu |
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| Rok vydání: | 2020 |
| Předmět: |
Ethanol
biology Traditional medicine Anemia business.industry medicine.medical_treatment 030231 tropical medicine Negative control Positive control Single injection biology.organism_classification medicine.disease Body weight 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Complementary and alternative medicine chemistry 030220 oncology & carcinogenesis medicine business Saline Cnidoscolus aconitifolius |
| Zdroj: | Journal of Complementary and Integrative Medicine. 18:87-92 |
| ISSN: | 1553-3840 2194-6329 |
| DOI: | 10.1515/jcim-2020-0006 |
| Popis: | Background The folkloric claim that Cnidoscolus aconitifolius (Chaya) could ameliorate anaemia requires scientific revalidation in anaemic models. Objective The aim of this study is to investigate the anti-anaemic effect of Cnidoscolus aconitifolius on cyclophosphamide-induced anaemia in rats. Methods The leaves of Cnidoscolus aconitifolius were collected, dried and extracted with ethanol. Twenty five Wistar Albino rats weighing 120–180 kg were used. Anaemia was induced in groups 2, 3, 4 and 5 with a single injection of cyclophosphamide, while group 1 served as a negative control without anemia and was treated with 0.5 mL of normal saline, Group 2 rats were treated with 100 mg/kg body weight of Cnidoscolus aconitifolius. Group 3 rats were treated with 500 mg/kg body weight of Cnidoscolus aconitifolius. Group 4 served as the positive control rats and was treated with 0.5 mL of normal saline. Group 5 which served as the standard control rats and were treated with 5 mg/kg body weight of standard drug Chemiron. The treated lasted for two weeks during which blood samples were collected from each rat for haematological analysis. Results The result shows that hematological parameters were elevated in groups 2, 3 and 5 rats treated with 100 mg/kg and 500 mg/kg body weight of ethanol extract of Cnidoscolus aconitifolius and chemiron respectively. Conclusions Ethanol leaf extract of Cnidoscolus aconitifolius at a graded dose of 500 mg/kg body weight had higher ameliorative effect on the haematological parameters of cyclophosphamide-induced anemia in rats. |
| Databáze: | OpenAIRE |
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