Synthesis of a Novel 1,4-Dicarbonyl Scaffold – Ethyl 3-Formyl-4,5-dihydrofuran-2-carboxylate – and Its Application to the Synthesis of Pyridazines

Autor:	Marcos A. P. Martins, Paulo A. Moraes, Helio G. Bonacorso, Adriano F. Camargo, Mário A. Marangoni, Nilo Zanatta
Rok vydání:	2020
Předmět:	Scaffold chemistry.chemical_compound chemistry Organic Chemistry Carboxylate Medicinal chemistry Catalysis
Zdroj:	Synthesis. 52:2528-2534
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-0039-1690886
Popis:	The 1,4-dicarbonyl scaffold ethyl 3-formyl-4,5-dihydrofuran-2-carboxylate was obtained through the rearrangement of the parent ethyl 2-(4,5-dihydrofuran-3-yl)-2-oxoacetate and applied to the synthesis of a series of 7-alkoxy-2,3-dihydrofuro[2,3-d]pyridazines. Twelve pyridazines­ were obtained in yields of up to 70%.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4d134608a8875dd940c3c81102d3711a https://doi.org/10.1055/s-0039-1690886 Zobrazit plný text záznamu