Stereoselective preparation of chiral compounds in Mannich-type reactions of a bicyclic imine and phenols or indole

Autor:	Elżbieta Wojaczyńska, Jakub Iwanejko, Jacek Wojaczyński, Julia Bąkowicz
Rok vydání:	2014
Předmět:	Indole test Bicyclic molecule Chemistry Betti reaction Organic Chemistry Imine Biochemistry chemistry.chemical_compound Nucleophile Yield (chemistry) Drug Discovery Organic chemistry Stereoselectivity Mannich reaction
Zdroj:	Tetrahedron Letters. 55:6619-6622
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2014.10.081
Popis:	Mannich-type reactions of a chiral bicyclic imine and various nucleophiles yield the corresponding adducts with good to high diastereoselectivity. The influence of the reaction conditions on the yield and stereochemical outcome is investigated. The configuration of the products is established by 1 H NMR spectroscopy, and the major isomers of two adducts are characterized by X-ray crystallography.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4d1341105bc7df22ea96430c0183191b https://doi.org/10.1016/j.tetlet.2014.10.081 Zobrazit plný text záznamu Full Text from ScienceDirect