Chemical Constituents of Nauclea latifolia and their Anti-GST and Anti-Fungal Activities
| Autor: | Athar Ata, Wadim L. Matochko, Peter N. Uzoegwu, Paul Holloway, Michael O. Eze, Chibuike C. Udenigwe |
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| Rok vydání: | 2009 |
| Předmět: |
Pharmacology
Nauclea biology Traditional medicine Metabolite Anti fungal Plant Science General Medicine biology.organism_classification chemistry.chemical_compound Complementary and alternative medicine chemistry Rhizopus circinans Chemical constituents Drug Discovery Lactam Organic chemistry Whole cell Quinovic acid |
| Zdroj: | Natural Product Communications. 4:1934578X0900400 |
| ISSN: | 1555-9475 1934-578X |
| DOI: | 10.1177/1934578x0900400905 |
| Popis: | The crude ethanolic extract of Nauclea latifolia yielded five known compounds, strictosamide (1), naucleamides A (2), naucleamide F (3), quinovic acid-3-O-β-rhamnosylpyranoside (4), and quinovic acid 3-O-β-fucosylpyranoside (5). Microbial reactions, using a whole cell culture of Rhizopus circinans on compound (1), yielded three analogues, 10-hydroxystrictosamide (6), 10-4bT-glucosyloxyvincoside lactam (7) and 16,17-dihydro-10-β-glucosyloxyvincoside lactam (8). Compounds 1-8 were identified with the aid of extensive NMR spectral studies. Compound 8 was found to be a new metabolite. Compounds 1-8 exhibited different levels of anti-GST and antifungal activities. |
| Databáze: | OpenAIRE |
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