| Popis: |
Schizophrenia and bipolar disorder represent serious mental disorders with polygenic inheritance. Neurocognitive deficits have been linked to psychotic phenomena and are candidate endophenotype for the illness. We have analyzed the case of a family consisting of mother diagnosed with bipolar disorder, a daughter with schizophrenia and one free of psychiatric disorders. The genetic associations between a functional polymorphism in the MTHFR, COMT, APOE and MnSOD genes and cognition have been investigated. Genotyping was carried out using a PCR-RFLP method. Neuropsychological tests regarding executive functions (WCST, TMT-B), memory (RAVLT), attention (TMT-A) and phonetic and semantic verbal fluency have been applied. No significant association was found. |
