Application of NMR and Mass Spectrometry to the Study of Drug Hydroxylation

Autor:	A. Gray, C. W. Vose, R. D. Brownsill, C. M. Walls
Rok vydání:	1988
Předmět:	Hydroxylation Drug chemistry.chemical_compound Metabolic pathway chemistry Stereochemistry media_common.quotation_subject Metabolite Mass spectrometry Xenobiotic media_common
Zdroj:	Bioanalysis of Drugs and Metabolites, Especially Anti-Inflammatory and Cardiovascular ISBN: 9781475794267
DOI:	10.1007/978-1-4757-9424-3_51
Popis:	Hydroxylation is probably the most common Phase I metabolic pathway for xenobiotics. It is also a pathway readily detectable by MS from the 16 a.m.u. mass shift for the metabolite ions relative to those of the parent compound. However, such information may sometimes be misleading, and MS does not always allow assignment of the site of hydroxylation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4cf334bf3c784dfffbb847815d8e4429 https://doi.org/10.1007/978-1-4757-9424-3_51 Zobrazit plný text záznamu