Synthesis of new hetero- and carbocyclic aromatic amides of glycyrrhizic acid as potential anti-HIV agents

Autor:	R. M. Kondratenko, L. A. Baltina, L. A. Baltina., O. A. Plyasunova, A. G. Pokrovskii, G. A. Tolstikov
Rok vydání:	2009
Předmět:	Pharmacology Anti hiv activity chemistry.chemical_compound Chemistry Stereochemistry Anti hiv Sulfapyridazine Amide Drug Discovery Pharmacology toxicology Sulfadimezine Selectivity Licorice root extract
Zdroj:	Pharmaceutical Chemistry Journal. 43
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-009-0316-x
Popis:	Members of a new group of di- and trisubstituted amides of glycyrrhizic acid (GA), the major component of licorice root extract, were synthesized; derivatives contained fragments of heterocyclic and aromatic amines (2-aminopyridine, 4-aminopyridine, 5-aminouracil, sulfadimezine, sulfapyridazine, and L-histidine methyl ester) using the dicyclohexylcarbodiimide method. Amides of GA containing 2-aminopyridine and 5-aminopurine residues had anti-HIV-1 activity in MT-4 cell cultures. The index of selectivity (IS) of the amide of GA with 5-aminouracil was, using various parameters, from 27.73 to 277.32, exceeding values for GA (from 4.45 to 24.0).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4ceb26f3a7aef7a37900c8ca05343556 https://doi.org/10.1007/s11094-009-0316-x Zobrazit plný text záznamu Full text from SpringerLink