Disseminierte Kryptokokkose bei zwei AIDS-Patienten: Ein Beitrag zur Kryptokokkose-Diagnostik bei AIDS

Autor:	Gertrud Rögler, Luise Prüfer-Krämer, H. D. Pohle, F. Staib, M. Seibold, D. Eichenlaub
Rok vydání:	2008
Předmět:	Cryptococcus neoformans Pathology medicine.medical_specialty biology business.industry Spleen General Medicine medicine.disease biology.organism_classification Flucytosine medicine.anatomical_structure Cerebrospinal fluid Antigen Amphotericin B Cryptococcosis Medicine business Mycosis medicine.drug
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 111:1061-1065
ISSN:	1439-4413 0012-0472
DOI:	10.1055/s-2008-1068584
Popis:	In two AIDS patients (homosexual men) microscopical demonstration of Cryptococcus neoformans in samples obtained by puncture of the liver (n = 1) and additionally of the spleen (n = 1) led to the diagnosis of systemic cryptococcosis. Using the India ink method capsulated Cryptococcus neoformans cells could also be detected in cerebrospinal fluid (CSF) and urine. Concomitant culture of the fungus from tracheal secretion, CSF, urine and faeces confirmed the diagnosis of a disseminated infection; the identification and germ count of C. neoformans was achieved by means of the differential-selective medium Guizotia-abyssinica-creatinine agar. The C. neoformans antigen titres in serum and CSF corresponded to the stage of the mycosis as detected by microscopy and culture. After a six-week course of treatment with amphotericin B and flucytosine (Ancotil), the fungus could no longer be isolated from the materials examined in one patient. Mycological monitoring aiming at the detection of C. neoformans in the tracheal secretions by means of the mentioned differential-selective medium is therefore recommended as a prophylactic measure in AIDS patients and persons at risk.
Databáze:	OpenAIRE
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