Comparison of Age-Related Bone Changes between Mini Rats and Wistar Rats

Autor:	Yoshiro Tani, Munehiro Teranishi, Sunao Manabe
Rok vydání:	1998
Předmět:	Bone growth medicine.medical_specialty Transgene Plasma gh Biology Toxicology medicine.disease Pathology and Forensic Medicine Osteopenia Rat growth hormone Endocrinology Age related Internal medicine medicine Femur Tartrate-resistant acid phosphatase
Zdroj:	Journal of Toxicologic Pathology. 11:137-143
ISSN:	1881-915X 0914-9198
DOI:	10.1293/tox.11.137
Popis:	It has been reported that in Mini rats, rats of transgenic Jcl: Wistar-TgN (ARGHGEN) 1Nts strain, the expression of rat growth hormone (GH) gene was suppressed by the presence of an antisense transgene, resulting in lowered plasma GH levels compared with nontransgenic Wistar rats. GH is thought to have an important role in bone growth, but bone changes of Mini rats have not been reported. In the present study, we examined the femurs of both male Mini rats and male Wistar rats at different ages, i.e. 8 and 22 weeks of age, and compared them between both rat strains. As a result, Mini rats showed smaller sizes of the femur with low mineral densities histologically characterized by the metaphyseal and diaphyseal bone be a possible animal model for osteopenia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4cd6b26399fd504e0762452c0ea5e701 https://doi.org/10.1293/tox.11.137 Zobrazit plný text záznamu