Schwere Osteoporose bei einer jungen Patientin mit Morbus Crohn

Autor:	K.-E. Maier, U. V. Gaisberg, B. Neef, E Höring
Rok vydání:	2008
Předmět:	medicine.medical_specialty Osteomalacia medicine.diagnostic_test Bone disease business.industry Osteoporosis General Medicine Lumbar vertebrae medicine.disease Gastroenterology Osteopenia medicine.anatomical_structure Calcitonin Internal medicine Biopsy medicine Vitamin D and neurology business
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 116:1055-1060
ISSN:	1439-4413 0012-0472
DOI:	10.1055/s-2008-1063717
Popis:	Increasing pain in the region of the lumbar vertebrae occurred in a 23-year-old woman known for the past 6 1/2 years to have Crohn's disease affecting the ileocolon. Radiology revealed marked osteopenia with collapse and deformation of the vertebral bodies. The only pointer to a bone disease was a markedly lowered serum level of 25-OH-vitamin D (less than 10 ng/ml). Biopsy from the ileal crest revealed pure osteoporosis without osteomalacia. Decisive pathogenetic factors were, in the main, glucocorticoid medication, malnutrition and the long duration of Crohn's disease. During treatment with monofluorophosphate, 152 g daily, in fixed combination with 600 mg calcium as well as calcitonin (initially 100 I.U. daily subcutaneously for two weeks, then 100 I.U. every other day s.c.) and vitamin D (3 x 1,000 I.U. daily by mouth) she became free of symptoms, and she has remained so for 9 months.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4ccff1e5debbdac494c7c45e3d30f22c https://doi.org/10.1055/s-2008-1063717 Zobrazit plný text záznamu