Manifestations related to alterations in coagulation in systemic lupus erythematosus of juvenile onset. Case report and literature review

Autor: Pilar del Rosario Guarnizo Zuccardi, Lyda Rengifo, Lina María Saza Mejía, María Fernanda Reina Ávila, Sandra Patricia Garcés Sterling
Rok vydání: 2020
Předmět:
Zdroj: Revista Colombiana de Reumatología (English Edition). 27:190-201
ISSN: 2444-4405
DOI: 10.1016/j.rcreue.2019.01.011
Popis: Hematological alterations are common in patients with systemic lupus erythematosus (SLE). These hematological manifestations may be expressed related to the involvement of cells affected and coagulation changes. The compromise in coagulation is associated with thrombotic manifestations. Risk factors associated with thrombosis have been described, such as the presence of elevated levels of homocysteine, acquired deficit of protein S, protein C, and antithrombin. However, the hemorrhagic diathesis has also been described at a lower frequency and related to the acquired deficiency of coagulation factors caused by the development of autoantibodies directed against coagulation factors. The cases are presented of 3 patients with juvenile SLE with unusual hematological manifestations, as well as a review of the literature in relation to them. The hematological manifestations in juvenile SLE are not only related to alterations in cell lines, vascular thrombosis and bleeding disorders should also be suspected. Early diagnosis and treatment reduces morbidity and mortality related to this type of manifestations.
Databáze: OpenAIRE
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