Controllable NO release from Cu1.6S nanoparticle decomposition of S-nitrosoglutathiones following photothermal disintegration of polymersomes to elicit cerebral vasodilatory activity
| Autor: | Ian Liau, Po-Tsung Kao, I-Ju Lee, Chen-Sheng Yeh |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Chemistry
Nanotechnology Vasodilation 02 engineering and technology General Chemistry Pharmacology Photothermal therapy 010402 general chemistry 021001 nanoscience & nanotechnology medicine.disease_cause 01 natural sciences 0104 chemical sciences Nitric oxide chemistry.chemical_compound In vivo Polymersome Systemic administration medicine medicine.symptom 0210 nano-technology Vasoconstriction Oxidative stress |
| Zdroj: | Chemical Science. 8:291-297 |
| ISSN: | 2041-6539 2041-6520 |
| DOI: | 10.1039/c6sc02774a |
| Popis: | Since the discovery of nitric oxide (NO) as a vasodilator, numerous NO therapies have been attempted to remedy disorders related to pathological vasoconstriction such as coronary artery disease. Despite the advances, clinical applications of NO therapies remain limited mainly because of the low stability of molecular NO donors (and NO molecules), and concerns about the increased oxidative stress and reduced arterial pressure associated with the systemic administration of NO. Here we design a photo-responsive polymersome with nitrosothiols and Cu1.6S nanoparticles in its core and shell, respectively, and demonstrate the photo-triggered release of NO and its vasodilatory activity on zebrafish. Unlike conventional approaches, our design enhances the stability of NO donors and prospectively enables spatiotemporal regulation of NO release, thus minimizing the harmful effects associated with conventional NO therapies. We anticipate that such a strategy will open up new clinical applications of NO and help reveal the complex biological effects of NO in vivo. |
| Databáze: | OpenAIRE |
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