ChemInform Abstract: SYNTHESIS OF 5-AZACYTIDINE-6-13C AND -6-14C

Autor:	Kenneth K. Chan, Wolfgang Sadee, James A. Staroscik
Rok vydání:	1977
Předmět:	Dimethyl acetal chemistry.chemical_compound Biliary excretion Hydrolysis chemistry Metabolite Dimethylformamide General Medicine Ring (chemistry) Cleavage (embryo) Medicinal chemistry Triazine
Zdroj:	Chemischer Informationsdienst. 8
ISSN:	0009-2975
DOI:	10.1002/chin.197736377
Popis:	5-Azacytidine (1) labeled with 13C or 14C at the chemically labile C-6 position was synthesized. A method utilizing hydrolytic opening of the triazine ring followed by recyclization with dimethylformamide dimethyl acetal was used. Urinary and biliary excretion was measured in rabbits following intravenous doses of 1-4-14C and 1-6-14C. Differences in recoveries of the dose from 4-14C and 6-14C demonstrate that ring cleavage of 1 with loss of the C-6 carbon represents a major metabolite route.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4cbede471b0fdabcd44afc51e796814b https://doi.org/10.1002/chin.197736377 Zobrazit plný text záznamu Plný text