Potentiation of general anaesthetic activity of ketamine by memantine

Autor:	T. M. Karthikeyan, K. Vasanthan, M. S. Umamageswari
Rok vydání:	2019
Předmět:	business.industry Anesthesia Memantine medicine Ketamine Long-term potentiation business General anaesthetic medicine.drug
Zdroj:	International Journal of Basic & Clinical Pharmacology. 9:146
ISSN:	2279-0780 2319-2003
Popis:	Background: The study was done with the objective to evaluate synergistic activity of ketamine induced general anesthesia by memantine in wistar albino rats.Methods: The wistar albino rats of either sex were divided into four groups of five animals. Group 1 received ketamine 40 mg/kg, group 2 received ketamine 80 mg/kg, group 3 received ketamine 40 mg/kg along with memantine 10 mg/kg and group 4 received 80 mg of ketamine along with memantine 10 mg/kg to evaluate the synergistic activity of ketamine induced general anesthesia by memantine. The sleep latency time and duration of sleep were measured in all the groups.Results: The sleep latency time of group 4 is significantly decreased (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4cb834776944104ad32e86f4c486038c https://doi.org/10.18203/2319-2003.ijbcp20195777 Zobrazit plný text záznamu