Changes in DNA Methylation Induced by Dioxins and Dioxin-Like Compounds as Potential Predictor of Disease Risk
| Autor: | Rubanovich Av, N. S. Kuzmina, T. M. Luong |
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| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
0303 health sciences biology Somatic cell Aryl hydrocarbon receptor 01 natural sciences Human genetics 03 medical and health sciences In vivo DNA methylation Genetics Disease risk biology.protein Cancer research heterocyclic compounds Epigenetics Dioxins and dioxin-like compounds 030304 developmental biology 010606 plant biology & botany |
| Zdroj: | Russian Journal of Genetics. 56:1180-1192 |
| ISSN: | 1608-3369 1022-7954 |
| Popis: | Dioxins and dioxin-like compounds are persistent organic pollutants (POPs) and technogenic ecotoxicants, the most dangerous of which is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). A peculiar feature of the considered genotoxicants that distinguishes them from other POPs is hormone-like activity, which is realized through binding to a special cellular protein, the Aryl hydrocarbon Receptor (AhR). In the present study, the phenomenological aspects of DNA methylation changes induced by dioxins and dioxin-like compounds and revealed in the studies in vitro and in vivo are considered. In animal models, multigenerational and transgenerational effects of dioxin-induced locus-specific DNA methylation changes and their association with reproductive dysfunctions and congenital malformations were firmly established. The importance of investigations of the long-term epigenetic consequences of human exposure to dioxins and the potential value of such studies for preventive diagnostics of somatic and reproductive pathologies are discussed. |
| Databáze: | OpenAIRE |
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