Double Minerals Ions Co-substituted Nano-Hydroxyapatite Based Biocomposite Implant for Biomedical Applications

Autor:	D. Madheswari, G. Priya, R. Sangeetha, P. Lavanya
Rok vydání:	2021
Předmět:	Chemistry Nano Nanotechnology 02 engineering and technology General Chemistry Implant Biocomposite 010402 general chemistry 021001 nanoscience & nanotechnology 0210 nano-technology 01 natural sciences 0104 chemical sciences Ion
Zdroj:	Asian Journal of Chemistry. 33:1409-1414
ISSN:	0975-427X 0970-7077
DOI:	10.14233/ajchem.2021.23077
Popis:	The biocomposite of cerium(III)-copper(II) minerals co-substituted hydroxyapatite (Ce-Cu-HA)/ poly(methyl methacrylate) (PMMA) was developed using a process of solvent evaporation. The analysis of X-ray diffraction (XRD), Fourier transform infrared (FT-IR), scanning electron microscope-energy dispersive X-Ray spectroscopy (SEM-EDX) confirmed the formation of Ce-Cu-HA in the PMMA matrix. In addition, the fabricated biocomposite demonstrated high antibacterial activity on Escherichia coli, which might be attributed to the action of Ce3+ and Cu2+ ions release on the substrate that blocks the cell transport pathways contributing to apoptosis. Biocomposites have been tested in osteoblast-like cells for their biological properties (biocompatibilty, alkaline phosphatase (ALP) activity and calcium deposition). Based on the present findings, it was proposed that Ce-Cu-HA/PMMA biocomposite could be a possible therapeutic candidate for bone tissue regeneration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4ca787767df2efeb4ffd222142638449 https://doi.org/10.14233/ajchem.2021.23077 Zobrazit plný text záznamu