In vivo Anticoccidial Efficacy of Calotropis procera Leaf Extract as an Alternative Treatment Against Eimeria papillate Infection in Mice
| Autor: | Mutee Murshed, Hossam M.A. Aljawdah, Mohammed M. Mares, Saleh Al-Quraishy |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Indian Journal of Animal Research. |
| ISSN: | 0976-0555 0367-6722 |
| DOI: | 10.18805/ijar.bf-1607 |
| Popis: | Background: Coccidiosis is still a serious parasite illness caused by Eimeria pps in many areas throughout the globe. As a consequence of eimeria medication resistance. Coccidiosis needs new drugs that contain natural antiparasitic chemical compounds. This study was conducted to investigate the in vivo anti-coccidia activity of Calotropis pocera leaf extract (CPLE) against infection of mice with Eimeria papillate. Methods: The first and second mouse groups were not infected, while the third, fourth, fifth and sixth were given 1x103 E. papillate sporulated oocysts. The fourth and fifth groups received 100 and 200 mg/kg CPLE orally and the sixth received toltrazuril 25 mg/kg in physiological saline. On day 5 p.i., animals were slaughtered and jejunum samples were prepared. Result: CPLE phytochemistry revealed 13 chemical compounds. 200 mg/kg was the most efficacious dose, reducing oocyst discharge in mouse faces by 68% and parasite stages in jejunal sections. Infection by E. papillata in mice causes inflammation, epithelial vacuolation, villi loss and a decrease in goblet cell density. When infected mice were given CPLE, histological damage was reduced by 69% and goblet cell number was restored to near-control levels. The infected group lost weight owing to emesis. However, the treated group CPLE gained weight. |
| Databáze: | OpenAIRE |
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