URINARY EXCRETION OF SERUM PROTEINS IN RENAL DISEASE
| Autor: | Renée Norberg, Sten Kistner |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Proteinuria medicine.diagnostic_test business.industry Renal function Glomerulonephritis Immunoelectrophoresis Bacteriuria Urine urologic and male genital diseases medicine.disease Blood proteins Excretion Endocrinology Internal medicine Internal Medicine medicine medicine.symptom business |
| Zdroj: | Acta Medica Scandinavica. 187:55-60 |
| ISSN: | 0001-6101 |
| DOI: | 10.1111/j.0954-6820.1970.tb02906.x |
| Popis: | Proteins in serum and concentrated urine from 41 patients suffering from renal diseases have been examined by electrophoresis in cellulose-acetate gel, immunoelectrophoresis, and estimation of the immunoglobulin content. Clearance of electrophoretic fractions and immunoglobulins was assessed and each value was expressed as a proportion of the albumin clearance. Patients with pyelonephritis and polycystic kidneys excreted relatively more globulin than did patients with glomerulonephritis, diabetic nephropathy, SLE, and renal amyloid. The difference was most marked in the case of β-globulin, and immunoelectrophoretic analysis showed that this fraction in the first-named patient group consisted almost exclusively of transferrin. Immunoglobulin excretion showed no marked difference between the patient groups, with the exception that the urine of the pyelonephritis and the polycystic-kidney patients always had a low content of IgA. Other variations could be attributed to variations in the total protein clearance. The presence of bacteriuria did not influence the composition of the urine protein. High clearance of protein was noted only in patients with relatively well preserved renal function. In pyelonephritis the proteinuria was similar at different degrees of renal failure. The results are discussed with respect to the origin of proteinuria associated with renal tubular disease. |
| Databáze: | OpenAIRE |
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