| Autor: |
J. Cashman, D Kalousek, I. Dubé, A. Eaves, C. Eaves, L Coulombel |
| Rok vydání: |
1985 |
| Předmět: |
|
| Zdroj: |
Modern Trends in Human Leukemia VI New Results in Clinical and Biological Research Including Pediatric Oncology ISBN: 9783540153290 |
| Popis: |
An analysis of mechanisms that underlie abnormal hemopoiesis requires methods that allow the cell populations involved to be characterized and quantitated under conditions that can be defined, and ideally manipulated. Although such methodologies are not yet fully developed, the past 2 decades have seen major advances in several areas relevant to this need. Of major importance has been the establishment of semisolid culture systems capable of supporting the short-term clonal growth and differentiation of individual primitive human hemopoietic progenitor cells of various types. These include pluripotent progenitors [1] as well as different classes of lineage-restricted progenitors [2–4]. Also noteworthy has been the successful exploitation of various genetic markers to examine the cell of origin of the abnormal clone in rare patients who are constitutional mosaics and in whom a clonal hemopoietic neoplasm [5, 6] has subsequently developed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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