XRCC1 codon 399 polymorphism (RS25487) in the Ukrainian population

Autor:	Ostapchenko Li, Yu. V. Vitruk, O. Stakhovskyi, V. B. Katrii, A. A. Kononenko, S. Ye. Shkliar, Ye. V. Kharkivska, E. O. Stakhovskyi, S. V. Demydov, S. V. Serha, Ya. M. Mishchuk, Iryna Kozeretska, O. K. Koliada
Rok vydání:	1970
Předmět:	Genetics XRCC1 education.field_of_study Polymorphism (computer science) Ukrainian Population language Biology education language.human_language
Zdroj:	Faktori eksperimental'noi evolucii organizmiv. 21:325-329
ISSN:	2415-3826 2219-3782
DOI:	10.7124/feeo.v21.861
Popis:	Aim. To estimate the frequency of XRCC1 codon 399 polymorphic variants in bladder cancer patients and in a control group and define association of this polymorphism with a bladder cancer in Ukrainian patients. Methods. We determined the allele frequencies for 111 patients and 92 controls. Genotyping was performed by PCR-RELP method. Results. The distribution of genotypes in control group was: Arg/Arg – 48 % (n=44), Arg/Gln – 41.3 % (n=38), Gln/Gln – 10.7 % (n=10), whereas in group of patients with a bladder cancer the following distribution was observed: Arg/Arg – 56.8 % (n=63), Arg/Gln – 27.9 % (n=31), Gln/Gln – 15.3 % (n=17). Genotype distribution in control group was within Hardy-Weinberg equilibrium (χ2=59.7, p
Databáze:	OpenAIRE
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