THE PRESENCE OF ANTI-PHOSPHATIDYLETHANOLAMINE ANTIBODIES IN ACUTE MYOCARDIAL INFARCTION
| Autor: | Mohammad Shojaei, Abdolhossien Madani, Mohammad Reza Farjam, Abdolreza Sotoodeh Jahromi |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
biology
business.industry Significant difference medicine.disease medicine.disease_cause General Biochemistry Genetics and Molecular Biology Autoimmunity Pathogenesis Immunology biology.protein Medicine In patient cardiovascular diseases Positive test Myocardial infarction Elisa method Antibody General Agricultural and Biological Sciences business |
| Zdroj: | OnLine Journal of Biological Sciences. 13:126-130 |
| ISSN: | 1608-4217 |
| Popis: | Acute Myocardial Infarction (AMI) is a clinical man ifestation of coronary atherothrombosis and is the important causes of death. Many factors play a role in AMI. Anti-Phospholipid (aPL) antibodies may act in the induction of immunological response lead ing to the development of AMI. AntiPhosphatidylethanolamine (aPEA) antibody has been detected in various autoimmune diseases and anti-phospholipid antibody syndrome. The study of a PEA antibody in AMI might shed light on etiologic mechanisms in the pathogenesis of coronar y atherothrombosis and AMI. This study was aimed to evaluate whether prevalence of aPEA antibodies, in patients with AMI and to analyze their relationship with traditional cardiovascular risk f actors. The prevalence of aPEA IgG and IgM in a well characterized group of patients with AMI as a case group and in age and sex matched healthy subjects as a control group. Sera from two groups w ere tested to evaluate the presence of aPEA IgG and IgM isotypes by ELISA method. The frequencies of positive test for aPEA IgG were 12.22 and 2.22% among patients and controls respectively with significant difference (p = 0.007). The aPEA IgM frequencies were 3.33 and 0.00% in patients and the controls, with significant difference (p = 0.005). According to the results of this study, aPEA antibo dies have a role in AMI, independent risk factors for AMI, which may represent a link between autoimmunity and coronary atherothrombosis. Further studies with larger sample size of patients and hea lthy people are needed to explore the role of aPEA antibodies in coronary atherothrombosis. |
| Databáze: | OpenAIRE |
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