Glutathione S-Transferase M1, GSTT1 and GSTP1 Genetic Polymorphisms and the Risk of Age-Related Macular Degeneration
Autor: | Beril Kucumen, Melda Yenerel, Bahadir Batar, Mehmet Güven, Adnan Yuksel, Mustafa Unal, Ebru Gorgun, Gülgün S. Güven, Umut Asli Dinc, Tümer Ulus |
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Rok vydání: | 2011 |
Předmět: |
Genetics
biology General Medicine Glutathione Macular degeneration urologic and male genital diseases medicine.disease Sensory Systems Cellular and Molecular Neuroscience Ophthalmology chemistry.chemical_compound GSTP1 Glutathione S-transferase chemistry Age related medicine biology.protein neoplasms |
Zdroj: | Ophthalmic Research. 46:31-37 |
ISSN: | 1423-0259 0030-3747 |
Popis: | Purpose: To determine the possible effects of glutathione S-transferase (GST) M1, GSTT1 and GSTP1 genetic polymorphisms on the risk of developing age-related macular degeneration (AMD). Patients and Methods: This case-control study included a total of 120 patients with AMD (65 with dry-type AMD and 55 with wet-type AMD) and 198 disease-free controls. GSTM1 and GSTT1 polymorphisms were analyzed by using a multiplex polymerase chain reaction (PCR), and GSTP1 polymorphism was detected by real-time PCR assay. Results:GSTM1-null genotype was significantly associated with the development of AMD (p = 0.01, OR = 1.82, 95% CI = 1.14–2.91). Stratification by AMD subtypes revealed a significant relationship between GSTM1-null genotype and dry-type AMD (p = 0.02, OR = 1.98, 95% CI = 1.10–3.53). In a stepwise regression model, only GSTM1-null genotype was significantly associated with the development of AMD (p = 0.01, OR = 1.77, 95% CI = 1.11–2.81). Conclusions: Our findings suggest that genetic polymorphisms of GST may have a role in the development of AMD. |
Databáze: | OpenAIRE |
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