Abstract 14660: The Ascvd-10 Risk Estimate as a Predictor for True Resistant Hypertension in High-risk Overweight and Obese Hypertensive Subjects: A Cross-sectional Study
| Autor: | Karan Sud, Lingling Wu, Faris Haddadin, Claire Huang Lucas, Sananda Moctezuma, Joshua Berookhim, Alba Munoz Estrella, Edgar Argulian, Dipal Patel |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Circulation. 142 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/circ.142.suppl_3.14660 |
| Popis: | Background: The estimates of 10-year risk for atherosclerotic disease (ASCVD-10) is applicable for individuals who are 40 to 79 years old without prior cardiovascular disease. While multiple components of the risk estimator are shared risk factors for many cardiovascular diseases, the ASCVD-10 does not consider the BMI value and limited studies examined the relationship between the ASCVD-10 risk score and resistant hypertension (RH). Methods: This is a cross-sectional study based on an out-patient primary care practice conducted between Oct 2017 to Oct 2018. Subjects with hypertension with either high-risk overweight (BMI ≥27 & ≤29.9 kg/m2 plus ≥1 obesity-related comorbid conditions) and subjects with obesity (BMI ≥30 kg/m2) were included. Subjects with prior ASCVD were excluded. Apparent treatment-resistant hypertension (ATRH) detected with an average of two blood pressure (BP) readings at the office was confirmed with home BP measurement to exclude pseudoresistance and verify true resistant hypertension (TRH). BP cutoff of >130/80 mmHg was used. Multivariate logistic regression adjusted for significantly different baseline variables among subjects with TRH vs non-TRH was used to examine the performance of ASCVD-10 in predicting TRH. Variables that are part of the ASCVD-10 score were excluded from the adjustment. Results: We identified 595 eligible subjects. Mean age was 60.4 years and 381 (64.1%) were females. ATRH was detected in 69 subjects but only 35 subjects had TRH after home BP measurement confirmation. Subjects with TRH compared to non-TRH were more likely to be of black race (51.4% vs 33.1%, p=0.022), to have chronic kidney disease (34.2% vs 11.3%, p Conclusion: The ASCVD-10 risk score can possibly be used as a predictor for the risk of having or developing RH in subjects with obesity or high-risk overweight. |
| Databáze: | OpenAIRE |
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