1-Methoxypyrrole-2-carboxamide—A new pyrrole compound isolated from Streptomyces griseocarneus SWW368
| Autor: | Jirayut Euanorasetr, Watsapon Wattanasuepsin, Yoshihiro Watanabe, Bungonsiri Intra, Watanalai Panbangred, Ratchanee Mingma, Wataru Fukasawa, Atsuko Matsumoto, Kazuro Shiomi, Mihoko Mori |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
biology Stereochemistry medicine.drug_class Chemical structure 030106 microbiology Carboxamide biology.organism_classification Applied Microbiology and Biotechnology Microbiology Kocuria rhizophila Xanthomonas campestris 03 medical and health sciences chemistry.chemical_compound Biochemistry chemistry Streptomyces griseocarneus Amide medicine Hevea brasiliensis Pyrrole |
| Zdroj: | The Journal of General and Applied Microbiology. 63:207-211 |
| ISSN: | 1349-8037 0022-1260 |
| DOI: | 10.2323/jgam.2016.10.006 |
| Popis: | A new pyrrole compound, 1-methoxypyrrole-2-carboxamide, was obtained from a culture broth of Streptomyces griseocarneus SWW368, which was isolated from the rhizospheric soil under a Para rubber tree (Hevea brasiliensis). The chemical structure was elucidated by 1D NMR, 2D NMR, and MS, as a pyrrole ring with a N-methoxy group and a primary amide group. It exhibited antibacterial properties against Kocuria rhizophila, Staphylococcus aureus and Xanthomonas campestris pv. oryzae; however, cytotoxicity of the compound at 714 μM against several mammalian tumor cell lines, i.e. A549, PANC1, HT29, HT1299 and HeLa S3, were not detected. |
| Databáze: | OpenAIRE |
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