Organ microcirculatory disturbances in experimental acute pancreatitis: a role of nitric oxide
| Autor: | M Dobosz, S Hac, L Mionskowska, D Dymecki, S Dobrowolski, Z Wajda |
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| Rok vydání: | 2005 |
| Předmět: | |
| Zdroj: | Physiological Research. :363-368 |
| ISSN: | 1802-9973 0862-8408 |
| DOI: | 10.33549/physiolres.930637 |
| Popis: | Microcirculatory disturbances are important early pathophysiological events in various organs during acute pancreatitis (AP). The aim of the study was to investigate an influence of L-arginine (nitric oxide substrate) and NG-nitro-L-arginine (L-NNA, nitric oxide synthase inhibitor) on organ microcirculation in experimental acute pancreatitis induced by four consecutive intraperitoneal cerulein injections (15 μg/kg/h). The microcirculation of pancreas, liver, kidney, stomach, colon and skeletal muscle was measured by laser Doppler flowmeter. Serum interleukin 6 and hematocrit levels were analyzed. AP resulted in a significant drop of microperfusion in all examined organ. L-arginine administration (2x100 mg/kg) improved the microcirculation in the pancreas, liver, kidney, colon and skeletal muscle, and lowered hematocrit levels. L-NNA treatment (2x25 mg/kg) caused aggravation of edematous AP to the necrotizing situation, and increased IL-6 and hematocrit levels. A further reduction of blood perfusion was noted in the stomach only. It is concluded that L-arginine administration has a positive influence on organ microcirculatory disturbances accompanying experimental cerulein-induced AP. NO inhibition aggravates the course of pancreatitis. |
| Databáze: | OpenAIRE |
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