A pilot study evaluating the safety and impact of pretreatment with metformin on colorectal cancer stem cells (CCSC) in patients undergoing resection
| Autor: | Shrikar Rajagopal, Martin D. Goodman, Jennifer Caplain, Nicholas C. DeVito, Bruce A. Orkin, Philip N. Tsichlis, Robert E. Martell, Elizabeth Grimm, Wasif M. Saif, Daniel Popowich |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Pathology Chemotherapy Cell type Colorectal cancer business.industry medicine.medical_treatment medicine.disease_cause medicine.disease Metformin Cancer stem cell Internal medicine Cancer cell medicine Stem cell Carcinogenesis business medicine.drug |
| Zdroj: | Journal of Clinical Oncology. 32:e14581-e14581 |
| ISSN: | 1527-7755 0732-183X |
| DOI: | 10.1200/jco.2014.32.15_suppl.e14581 |
| Popis: | e14581 Background: The cancer stem cell (CSC) hypothesis of tumorigenesis suggests that unlike most cancer cells within a tumor CSC resist chemotherapy and can regenerate various cell types in tumo... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|