Dipolar Cycloaddition Route to the Synthesis of 1a,25-Dihydroxy-26-norvitamin D2 Derivatives

Autor:	Peter M. Wovkulich, Bernard Michael Hennessy, Enrico G. Baggiolini, Milan R. Uskokovic
Rok vydání:	1993
Předmět:	Pharmacology chemistry.chemical_classification Intramolecular reaction Bicyclic molecule Chemistry Stereochemistry Organic Chemistry Diastereomer Cycloaddition Analytical Chemistry Nitrone chemistry.chemical_compound Acyl chloride Intramolecular force Aliphatic compound
Zdroj:	HETEROCYCLES. 35:791
ISSN:	0385-5414
DOI:	10.3987/com-92-s(t)53
Popis:	The intramolecular dipolar cycloadditions of nitrones derived from aldehydes (8) and (14) were found to proceed with a high degree of diastereoselectivity. By taking advantage of the functionality and stereochemical features residing in the cycloadducts (10) and (11), respectively, the two novel vitamin D 2 derivatives (1c) and (1d) were synthesized
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4c538bf29e7238df8372081af4cf21b6 https://doi.org/10.3987/com-92-s(t)53 Zobrazit plný text záznamu