Photophysical characterization of far-red absorbing photosensitizers in cyclodextrin solutions

Autor:	Carsten Zimmermann, Ralf Herter, Beate Roeder
Rok vydání:	1995
Předmět:	chemistry.chemical_classification Naphthalocyanine Cyclodextrin Chemistry medicine.medical_treatment Photodynamic therapy Photochemistry carbohydrates (lipids) chemistry.chemical_compound Pheophorbide A polycyclic compounds medicine Molecule Photosensitizer Absorption (chemistry) Luminescence
Zdroj:	Proceedings of SPIE.
ISSN:	0277-786X
DOI:	10.1117/12.199181
Popis:	One of the most important problems for clinical use of photodynamic therapy is the selective accumulation of photosensitizer molecules by the tumor tissue. Possibly cyclodextrins could be used to solubilize and transport hydrophobic dyes to the target. Until now it has not been investigated to what extent the dye-cyclodextrin complexation alters the photophysical properties of the dye molecules important for their photodynamic activity. For this reason we investigated the behavior of three sensitizers belonging to different chemical classes: pheophorbide a, octa-(alpha) -butyloxy-Zn-phthalocyanine, and tetra-tert-butyl-Zn- naphthalocyanine in cyclodextrin solutions.
Databáze:	OpenAIRE
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