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Toxocariasis is a helminthic disease with a chronic course caused by the larval stages of the nematode Tox-ocara canis. The problem of toxocariasis is important for both humane and veterinary medicine. Therefore, the work aimed to study the morphological parameters of the blood of dogs in experimental toxocariasis.The 12 dogs aged 2 to 4 months were used for research studies. Two groups were formed of six animals in each: control and experimental. Puppies of the experimental group (E) were infected with the causative agent of toxocariasis at a dose of 5000 invasive eggs of Toxocara canis per kg of body weight. The control puppies (C) were clinically healthy. Toxocariasis in dogs suppresses the hematopoietic function of the bone marrow, resulting in a decrease in the number of erythrocytes and hemoglobin in their blood. It was found that on the 30th day of the research, the erythrocytes count in the blood of the (E)group of dogs was the lowest, where, accordingly, this figure decreased by 37.5% relative to control values. Along with a fall of in the range of erythrocytes in infected dogs showed a reduction in hemoglobin. Probable decrease in the level of hemoglobin in the blood of dogs of the (E) group was observed on 20, 25 and 30 days of the experiment, where compared with the control, this figure declined by 22.9, 26.1 and 27.3%, respectively. In the study of the leukocytes count in the blood of dogs with experimental toxoca-riasis, an increase in this indicator was found throughout the research period. The raise of leukocytes in the blood of infected dogs indicates the growth in the leukopoietic function of the bone marrow, lymph nodes, and spleen, which are caused by Toxocara and their products of life. Eosinophilia was found in the blood of dogs of the (E) group, which reflects the intensity of the allergic reaction caused by the pathogen toxocariasis. In the toxocariasis in dogs, amount of eosinophils at 10 and 15 days of the experiment increased by 2.57 and 4.62% relative to control values. Along with eosinophilia in the blood of infected dogs, the raise in the count of neutrophils was also ob-served. The largest amount of neutrophils was in the blood of the (E) group of dogs on the 25th and 30th day of the study, compared with control values, it grew up by 2.0 and 2.24% rod-shaped and 4.17 and 5.85% segmental. When infected with toxocara, the number of lymphocytes in the blood of dogs at 10 and 15 days of the research decreased by 6.45 and 10.33% relative to the (C) group of animals. |
