Cresyl glycidyl ethers (o-isomer, isomer mixture)
| Autor: | Hartwig, Andrea, MAK Commission |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
(sub)chronic toxicity
Epoxidharz-Systeme 2-[(2-Methylphenoxy)methyl]oxiran [(o-tolyloxy)methyl]oxirane Sensibilisierung o-Kresylglycidylether glycidyl-o-tolyl ether sensitization epoxy resin systems ((o-Tolyloxy)methyl)oxiran [(tolyloxy)methyl]oxirane (sub)acute toxicity toxicokinetics Reaktivverdünner reactive diluent [(Tolyloxy)methyl]oxiran Kresylglycidylether (Isomerengemisch) irritation 2-[(2-methylphenoxy)methyl]oxirane cresyl glycidyl ether (isomer mixture) prenatal toxicity genotoxicity Glycidyl-o-tolylether (sub)akute Toxizität Reizwirkung 2 3-epoxypropyl-o-tolyl ether Genotoxizität Toxikokinetik Metabolismus glycidyl tolyl ether 2 3-Epoxypropyl-o-tolylether fruchtschädigende Wirkung o-cresyl glycidyl ether (sub)chronische Toxizität Glycidyltolylether metabolism [(Methylphenoxy)methyl]oxiran [(methylphenoxy)methyl]oxirane |
| DOI: | 10.34865/mb221079e6_3or |
| Popis: | The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated cresyl glycidyl ethers (o-isomer [2210-79-9], mixture of isomers [26447-14-3]) considering all toxicological end points. The critical effect of cresyl glycidyl ethers is skin sensitization in humans and animals. In rats, local irritation is observed after inhalation. Cresyl glycidyl ethers are a direct mutagen in bacteria and the mutagenicity is considerably reduced by adding S9-mix. In Big Blue mice, o-cresyl glycidyl ether was not mutagenic in the liver and testes up to oral doses of 500 mg/kg body weight and day. Thus, the substance is not systemically genotoxic. There are no carcinogenicity studies. In rats, the structurally analogous substance phenyl glycidyl ether induced nasal tumours after inhalation of 12 ml/m. Based on this structural relationship, cresyl glycidyl ethers are suspected of being locally acting carcinogens. They are therefore assigned to Carcinogen Category 3 B. As they are directly genotoxic in vitro and the local mutagenicity in vivo has not been clarified, a maximum concentration at the workplace (MAK value) cannot be derived. A prenatal toxicity study found no developmental toxicity in rats up to the highest dose tested of 600 mg/kg body weight and day. The contact sensitizing potential is confirmed by new clinical data in humans and animal studies and the previous “Sh” notation is retained. There are no data for respiratory sensitization. Skin contact is not expected to contribute significantly to systemic toxicity. |
| Databáze: | OpenAIRE |
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