| Autor: |
Srikanth Annareddygari, Venkateshwerreddy Kasireddy, Jayachandra Reddy, Shashidharreddy Shagum, Jyothi Vantikommu |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Letters in Drug Design & Discovery. 20:916-920 |
| ISSN: |
1570-1808 |
| Popis: |
Background: Nitrogen-rich heterocycles have occupied a special place in medicinal chemistry due to their exceptional biological activities. In that, thiazolo azapurines and pyrimido thiazolo azapurines are compounds of interest with their medicinal properties. Objective: The objective is to synthesize novel substituted thiazolo azapurines and pyrimido thiazolo azapurines and evaluate their biological activities. Methods: Herein, we have demonstrated the efficient synthesis of thiazole fused triazolo[4,5-d]pyrimidin- 7-ones starting from the easily accessible feedstock chemical cyano acetamide. The reaction proceeds under mild reaction conditions with diversified substrate scope. Results: Notably, the obtained compounds are further derivatized under various sets of conditions to give the corresponding nitrogen-rich tetracyclic core. All synthesized compounds were tested against four pathogenic microorganisms and some of the compounds were found potent with good inhibition. Conclusion: We have synthesized a diversely substituted nitrogen-rich thiazolo azapurines and pyrimido thiazolo azapurines and evaluated them for their anti-bacterial activity. All synthesized compounds were tested against four pathogenic microorganisms, and some of the compounds were found to be potent with good inhibition. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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