Loss of integrin 2 1 reduces tumour necrosis factor-dependent inflammatory cartilage destruction and matrix metalloproteinase expression through modulating extracellular signal-regulated kinase
| Autor: | Thomas Pap, Marvin A. Peters, D Wendholt, Svetlana Frank, George Kollias, Adelheid Korb, B Eckes, Simon Strietholt |
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| Rok vydání: | 2010 |
| Předmět: |
biology
business.industry Immunology Integrin Matrix metalloproteinase General Biochemistry Genetics and Molecular Biology Cell biology Collagen receptor Fibronectin Rheumatology Integrin alpha M biology.protein Immunology and Allergy Medicine Integrin-linked kinase Receptor business Type I collagen |
| Zdroj: | Annals of the Rheumatic Diseases. 69:A22-A23 |
| ISSN: | 0003-4967 |
| Popis: | Integrins are the main receptors for cell-matrix interactions and integrin signalling is critical for a variety of cellular functions such as adhesion, cell spreading and inflammatory responses. α2β1 integrin functions as a major receptor for type I collagen on a number of different cells, including fibroblasts and inflammatory cells. Although α2-deficient mice appear normal apart from mild platelet dysfunction, it was shown that α2β1 integrin contributes to the induction of matrix metalloproteinases (MMPs) in tissue remodelling. Based on the hypothesis … |
| Databáze: | OpenAIRE |
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