Immunological Tolerance to Erwinia carotovora L-Asparaginase

Autor:	A.P. Maclennan, L.A.E. Ashworth
Rok vydání:	1973
Předmět:	chemistry.chemical_classification biology Cyclophosphamide Immunogenicity Immunology General Medicine Erwinia biology.organism_classification Serum antibody L asparaginase Enzyme chemistry medicine biology.protein Immunology and Allergy Blood clearance Antibody medicine.drug
Zdroj:	International Archives of Allergy and Immunology. 45:915-929
ISSN:	1423-0097 1018-2438
DOI:	10.1159/000231090
Popis:	Mice and rabbits readily form antibodies in response to injections of Erwinia carotovora L-asparaginase (ASNase), and show accelerated blood clearance of the enzyme following treatment. In mice, by a suitable choice of dose of ASNase and schedule of administration, the immunological response could be minimized. There was evidence of specific immunological tolerance, shown more readily in terms of blood clearance than of serum antibody titres. A proportion of mice was also made tolerant using cyclophosphamide (CY) together with ASNase. In rabbits, the immunogenicity of ASNase could not be reduced in general, either by the use of centrifuged, aggregate-free enzyme, or by the use of reportedly tolerogenic regimens of CY or 6-mercaptopurine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4c369ab881903cbb7bd2bb8a44421c79 https://doi.org/10.1159/000231090 Zobrazit plný text záznamu