Response to Melatonin Treatment in Children With Autism spectrum Disorder and Relationship to Sleep Parameters and Melatonin Levels
| Autor: | Elena Martinez-Cayuelas, Milagros Merino-Andreu, Rebeca Losada-Del Pozo, Teresa Gavela-Pérez, Carmen Garcés, Leandro Soriano-Guillén |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Journal of Child Neurology. :088307382311736 |
| ISSN: | 1708-8283 0883-0738 |
| DOI: | 10.1177/08830738231173606 |
| Popis: | Melatonin is one of the most used pharmacologic treatments for sleep problems in autism spectrum disorder, though its relationship with circadian and sleep parameters is still not well stablished. A naturalistic study was conducted in children with autism spectrum disorder, previously drug-naïve, before and after treatment with immediate-release melatonin. Circadian rhythms and sleep parameters were studied using an ambulatory circadian-monitoring device, and saliva samples were collected enabling determination of dim light melatonin onset. Twenty-six children with autism spectrum disorder (age 10.50 ± 2.91) were included. Immediate-release melatonin modified circadian rhythm as indicated by wrist skin temperature, showing an increase at night. A positive correlation was found between time of peak melatonin and sleep efficiency improvement values. Sleep-onset latency and efficiency improved with immediate-release melatonin. Immediate-release melatonin could be an effective treatment to improve sleep onset and restore a typical pattern of wrist temperature, which appears to be lost in autism spectrum disorder. |
| Databáze: | OpenAIRE |
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