Quantitative pretreatment CT volumetry: Association with oncologic outcomes in patients with T4a squamous carcinoma of the larynx

Autor:	Merrill S. Kies, Renata Ferrarotto, Donald F. Schomer, G. Brandon Gunn, Amy C. Hessel, Jack Phan, J.A. Messer, William H. Morrison, Randal S. Weber, Katherine A. Hutcheson, David I. Rosenthal, Stephen Y. Lai, Brian Pham, Jay C. Shiao, Clifton D. Fuller, Mark Zafereo, Benjamin W. Warren, Beth M. Beadle, Abdallah S.R. Mohamed, Jason M. Johnson, Heiko Enderling, Mona Kamal, Adam S. Garden, Steven J. Frank, Jan S. Lewin
Rok vydání:	2017
Předmět:	Larynx Oncology medicine.medical_specialty Multivariate analysis business.industry medicine.medical_treatment Urology Cancer medicine.disease Primary tumor Squamous carcinoma Radiation therapy Laryngectomy 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Internal medicine Cohort medicine 030223 otorhinolaryngology business
Zdroj:	Head & Neck. 39:1609-1620
ISSN:	1097-0347 1043-3074
DOI:	10.1002/hed.24804
Popis:	Background The purpose of this study was to determine the impact of CT-determined pretreatment primary tumor volume on survival and disease control in T4a laryngeal squamous cell carcinoma (SCC). Methods We retrospectively reviewed 124 patients with T4a laryngeal cancer from 2000-2011. Tumor volume measurements were collected and correlated with outcomes. Results Five-year overall survival (OS) for patients with tumor volume ≥21 cm3 treated with larynx preservation (n = 26 of 41) was significantly inferior compared to
Databáze:	OpenAIRE
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