Sequential reactions from catalytic hydroformylation toward the synthesis of amino compounds

Autor:	Ana R. Almeida, Rui M. B. Carrilho, Mariette M. Pereira, Artur M. S. Silva, Artur R. Abreu, Andreia F. Peixoto
Rok vydání:	2017
Předmět:	Reaction conditions 010405 organic chemistry Organic Chemistry Strecker amino acid synthesis chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences Rhodium Catalysis chemistry Drug Discovery Organic chemistry Hydroformylation
Zdroj:	Tetrahedron. 73:2389-2395
ISSN:	0040-4020
DOI:	10.1016/j.tet.2017.03.023
Popis:	Different families of new amino compounds were efficiently synthesized, through optimized sequential processes, involving rhodium catalyzed hydroformylation as the key step. The selection of appropriate hydroformylation catalytic systems and reaction conditions allowed obtaining aldehydes derived from several n-alkyl olefins, cholest-4-ene and 3-vinyl-1H-indole, which were subsequently transformed, in one-pot, in to α-amino acids via hydroformylation/Strecker reaction, and in to tertiary amines via hydroaminomethylation, with excellent yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4c111681c800fd12f60a023ad21571ef https://doi.org/10.1016/j.tet.2017.03.023 Zobrazit plný text záznamu Full Text from ScienceDirect