Myeloperoxidase, protein carbonyls and oxidative stress in coronary artery disease
| Autor: | Suchitra Mm, Durgaprasad Rajasekhar, G. Tejaswi, P. V. L. N. Srinivasa Rao, VS Kiranmayi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Protein Carbonyl Content Inflammation 030204 cardiovascular system & hematology medicine.disease_cause Coronary artery disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine chemistry.chemical_classification Reactive oxygen species biology business.industry medicine.disease Malondialdehyde Ferric reducing ability of plasma 030104 developmental biology Endocrinology chemistry Myeloperoxidase Immunology biology.protein medicine.symptom business Oxidative stress |
| Zdroj: | Journal of Indian College of Cardiology. 7:149-152 |
| ISSN: | 1561-8811 |
| DOI: | 10.1016/j.jicc.2017.10.004 |
| Popis: | Objective Oxidative stress and inflammation play important roles in the pathogenesis of coronary artery disease (CAD). Myeloperoxidase (MPO) produced by circulating neutrophils plays an important role in both processes of inflammation and oxidative stress. MPO generates reactive oxygen species which cause oxidative damage to cellular lipids and proteins. Generation and accumulation of oxidative damage plays an proatherogenic role initiating a cascade of damaging cellular changes. This study was designed to evaluate the association of MPO with oxidative stress and to assess MPO as a predictor of CAD. Methods and results Thirty patients diagnosed with CAD following angiography along with thirty age matched healthy controls were taken into the study. CAD cases had significantly higher triglyceride (p = 0.012), lower HDL cholesterol, higher oxidative stress markers malondialdehyde (MDA), protein carbonyl content (PCO), and MPO levels and lower antioxidant ferric reducing ability of plasma (FRAP) levels in CAD patients when compared to controls (p Conclusion Our study shows that an increase in MPO levels is associated with oxidative stress and MPO is also observed to be a significant predictor of CAD. |
| Databáze: | OpenAIRE |
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