| Popis: |
Studies on neuronal nicotinic receptors really started with the experiments of LANGLEY and DICKENSON in 1889 on the cat superior cervical ganglion. In fact, they were not particularly interested in the action of nicotine as such, but were employing it as a tool to map out the distribution of the sympathetic fibres. For this, they used it as a blocking agent rather than as a stimulating agent. However, they did define its site of action quite precisely, as the following quotation from their paper shows |
