Circulating CD4+ CD28 Null T Cells and CD4+ CD28+ T Lymphocytes in Systemic Lupus Erythematosis
| Autor: | Maha A. Bassiouny, Khaled M. A. Elzorkany, Doaa M.S. El-Sayed, Enas S Essa |
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| Rok vydání: | 2018 |
| Předmět: |
Creatinine
education.field_of_study Systemic lupus business.industry Central nervous system Population CD28 T lymphocyte medicine.disease Pathogenesis chemistry.chemical_compound medicine.anatomical_structure chemistry Immunology medicine skin and connective tissue diseases education business Nephritis |
| Zdroj: | The Medical Journal of Cairo University. 86:3787-3791 |
| ISSN: | 2536-9806 |
| Popis: | Background: Systemic Lupus Erythematosis (SLE) is a chronic multi factorial systemic autoimmune disease which affects multiple organs such as joints, the skin, kidneys or central nervous system. T cells may be a contributing factor in pathogenesis of SLE.Aim of Study: The objective of this study was to evaluate senescent CD4+ CD28 null T lymphocytes and conventional CD4+ CD28+ T lymphocytes in SLE patients with and without nephritis.Subjects and Methods: The study was conducted on 51 patients with SLE; 21 patients with nephritis and 30 patients without nephritis, in addition to 15 age and sex matched healthy individuals as control. The CD4/CD28 expression on peripheral blood lymphocytes was measured for all study subjects using flowcytometry technique.Results: CD4+/CD28 null T-lymphocytes showed no statistically significant difference among the studied groups. Meanwhile, CD4+/CD28+ T lymphocytes were significantly higher SLE patients with nephritis than controls (p=0.009). There was significant positive correlation between CD4+/ CD28+ T lymphocyte population size and serum creatinine in SLE with nephritis (p=0.004).Conclusion: CD4+/CD28+ T lymphocyte population was higher in SLE patients with nephritis than controls and show statistically significant changes in correlation with serum creatinine level. |
| Databáze: | OpenAIRE |
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