SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF2,3-DIHYDRO-1H-PERIMIDINE DERIVATIVES
| Autor: | TUO, Nanou Tiéba, KANGAH, Niameke Jean Baptiste, BALLO, Daouda, SANHOUN, Aimé R., Kablan, Ahmont Landry Claude, KODJO, Charles Guillaume, YAPO, Ossey Bernard, ZIAO, Nahossé |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| DOI: | 10.48369/imist.prsm/jmch-v20i3.27197 |
| Popis: | We report here the synthesis, characterization and antimicrobial activity of three molecules from the family of 2,3-dihydro -1H-perimidines derived from 1,8-diaminonaphthalene. The three perimidines were characterized by conventional spectrometry methods (NMR and MS), then tested on bacterial strains. The three compounds 1-3 were shown to be active against the strain of bacteria Escherichia coli ATCC 25922, with MIC values of 7.5 mg / mL, 3.75 mg / mL and 60 mg / mL respectively. Salmonella typhimirium SO66 is active on compounds 1 and 2 at MIC values of 30 mg / mL and 60 mg / mL, respectively. Compound 1 is active on Staphylococcus aureus CIP 4,83 and Staphylococcus epidermidice CIP 54124 at MIC values of 7.5 mg / mL and 1.87 mg / mL and for compound 2 we have 3.75 mg / mL and 0.225 mg / mL respectively. The fungal strain of Candida Albicans ATCC 10234 showed resistance to compound 3 synthesized, but on the other hand Candida tropicalis ATCC 13803 was sensitive to all compounds with a MIC of 0.45 mg / ml for compound 1, 0.225 mg / ml for compound 2 and 3.75 mg / ml for compound 3. Therefore, the para position appears to be the least active position on the antimicrobial sources of this pharmacophore. Moroccan Journal of Heterocyclic Chemistry, Vol 20, No 3 (2021) |
| Databáze: | OpenAIRE |
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