| Autor: |
Bernardo Liberman, Marcelo Maia Pinheiro, Arthur Cukiert, Jayme Goldman, Luis R. Salgado, Marcia Nery |
| Rok vydání: |
1999 |
| Předmět: |
|
| Zdroj: |
Arquivos de Neuro-Psiquiatria. 57:686-688 |
| ISSN: |
0004-282X |
| Popis: |
Cushing's disease is rare in children and its ocurrence in identical twins is extremely rare. This paper reports on identical twins discordant for Cushing's disease. One of them first presented with a cushingoid phenotype by the age of 10. Her evaluation showed an increased urinary free-cortisol and serum ACTH. Her pattern in the dexametazone supression tests was compatible with Cushing's disease. MRI disclosed a pituitary macroadenoma which was removed by the transesphenoidal approach. Immunohistochemical studies of the tumor showed the presence of ACTH-producing cells. The patient went into clinical and laboratorial remission after surgery. She re-started to grow after the disappearance of the Cushing's phenotype but she is still shorter than her healthy sister. The latter remains disease-free 4 years after her sister's diagnosis. This represents the third such case reported in the literature. Our findings suggest that acquired factors may be responsible for the genesis of Cushing's disease. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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