Gestational Hypervolemic Hypertension Is Clinically Different from 'Classical' Preeclampsia

Autor:	József Bódis, Sára Jeges, Eszter Hantosi, Zsolt Ifi, Péter Tamás
Rok vydání:	2014
Předmět:	Cardiac output medicine.medical_specialty Fetus Pregnancy Proteinuria business.industry Obstetrics Birth weight medicine.disease Preeclampsia Endocrinology Internal medicine Moderate proteinuria Medicine Gestation medicine.symptom business
Zdroj:	OALib. :1-4
ISSN:	2333-9721 2333-9705
Popis:	Objective: Homogenous pathogenesis of preeclampsia has been challenged. We examined the clinical characteristics of preeclamptic patients with discordant fetal growth which is one of the controversial issues in preeclampsia. Methods: Clinical index values including central hemodynamics of third-trimester preeclamptic patients with distinct fetal birth weights (group A: birth weight ≥ 50th percentile; n = 23 and group B: birth weight < 50th percentile; n = 14) were compared. Results: Pregnant women of group A were characteristically obese and edematous, but no fetal complications were observed. Patients of group B were younger, onset of preeclampsia was earlier, proteinuria was more severe, and fetal compromise was frequent. A marked difference between the two groups was noticed in central hemodynamics as the mean of CO (cardiac output) was 8.5 and 5.6 l/min in group A and B, respectively (p < 0.001). CO of less than 7.45 l/min was found to be associated with fetal birth weight below 50th percentile (OR = 15.6; 95% CI: 3.2 and 45.8, p = 0.001). Conclusions: Augmented CO in pregnancy may ensure efficient placental blood supply, but it may cause hypertension with subsequent moderate proteinuria. This condition, however, seems to be different from the “classical” preeclampsia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4bc8147c3e44f6965b78919bd25da87a https://doi.org/10.4236/oalib.1100751 Zobrazit plný text záznamu