Interaction of the general volatile anesthetic Enflurane with bacteriorhodopsin-DPPC proteoliposomes
| Autor: | Nathalie Hauet, Maïté Paternostre, François Boucher, Daniel Letourneau |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Liposome
biology technology industry and agriculture Analytical chemistry Phospholipid Enflurane Photoprotein Bacteriorhodopsin Calorimetry Condensed Matter Physics chemistry.chemical_compound chemistry Phosphatidylcholine Anesthetic biology.protein medicine Biophysics lipids (amino acids peptides and proteins) Physical and Theoretical Chemistry medicine.drug |
| Zdroj: | Journal of Thermal Analysis and Calorimetry. 98:39-45 |
| ISSN: | 1572-8943 1388-6150 |
| DOI: | 10.1007/s10973-009-0424-6 |
| Popis: | Homogenous bacteriorhodopsin-DPPC proteo- liposomes were characterized and used as a target for the general anesthetic Enflurane. Dose-response curves for the protein and the lipids, in the very same sample, at high (2800) and low (360) lipid: bacteriorhodopsin molar ratios, were compared simultaneously. Above the main phase transition temperature of DPPC, there is no difference between the protein and lipid sensitivities toward the anesthetic. Below the main phase transition temperature of DPPC, the bacteriorhodopsin sensitivity toward Enflurane is much higher than that of lipids. Its dose-response curves reach saturation at anesthetic concentrations where their effect on lipids is barely visible, indicating that bulk lipids do not mediate the anesthetic action. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|