Iodine-induced coupling reaction forms C–S and C–N bonds to construct 3,4-heteroatom-Functionalized maleimides
| Autor: | Xiao-long He, Xue Tang, Zi-hua Yu, Si-yu Wen, Yujin Li, Cheng-xi Huang |
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| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Chemistry Organic Chemistry Heteroatom Intermolecular force chemistry.chemical_element 010402 general chemistry Iodine 01 natural sciences Biochemistry Coupling reaction 0104 chemical sciences Metal chemistry.chemical_compound visual_art Drug Discovery Polymer chemistry visual_art.visual_art_medium Thiol Amine gas treating Maleimide |
| Zdroj: | Tetrahedron. 97:132246 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2021.132246 |
| Popis: | Using iodine to induce the intermolecular thioamination reaction of maleimide, thiol and amine, various kinds of substituted 3-amino-4-thiomaleimides were obtained in good yields. This reaction was performed in THF at the presence of I2 and TBHP. On the basis of optimized conditions, a variety of thiophenols and amines were involved in the reaction. The method provided a new and green way for the thioamination of maleimide, in which heavy metal was avoided to use. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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