Labeled 2-deoxy-D-glucose analogs. 18F-labeled 2-deoxy-2-fluoro-D-glucose, 2-deoxy-2-fluoro-D-mannose and 14C-2-deoxy-2-fluoro-D-glucose

Autor:	David E. Kuhl, T. Ido, V Casella, Martin Reivich, Alfred P. Wolf, Joanna S. Fowler, C-N. Wan
Rok vydání:	1978
Předmět:	2 deoxy 2 18f fluoro d glucose Stereochemistry Organic Chemistry Cerebral glucose metabolism Mannose Biochemistry Analytical Chemistry chemistry.chemical_compound chemistry D-Glucose Drug Discovery Radiology Nuclear Medicine and imaging 2-Deoxy-D-glucose Spectroscopy
Zdroj:	Journal of Labelled Compounds and Radiopharmaceuticals. 14:175-183
ISSN:	0362-4803
DOI:	10.1002/jlcr.2580140204
Popis:	A convenient method for the synthesis of 18F-2-deoxy-2-fluoro-D-glucose (4) and 18F-2-deoxy-2-fluoro-D-mannose (8) by the direct fluorination of 3,4,6-tri-0-acetyl-D-glucal with 18F-F2 is described. 14C-2-deoxy-2-fluoro-D-glucose has been synthesized from 14C-3,4,6-tri-0-acetyl-D-glucal (from D-[14c(U)]-glucose) by fluorination with F2 (Method 1) and CF3OF (Method 2). These labeled analogs of 2-deoxy-D-glucose were required for the study of local cerebral glucose metabolism.
Databáze:	OpenAIRE
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