A Coleus forskohlii extract improves body composition in healthy volunteers: An open-label trial
| Autor: | Seika Kamohara, Somboon Noparatanawong |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Forskolin food.ingredient business.industry Physiology Coleus medicine.disease Obesity chemistry.chemical_compound Endocrinology food chemistry Internal medicine Weight management Basal metabolic rate medicine Lean body mass Composition (visual arts) business Body mass index |
| Zdroj: | Personalized Medicine Universe. 2:25-27 |
| ISSN: | 2186-4950 |
| DOI: | 10.1016/j.pmu.2013.04.003 |
| Popis: | Purpose Coleus forskohlii (CF) is a south Asian herb that has been historically used in Ayurvedic medicine. The root of CF contains forskolin, a biologically active compound that has been demonstrated to improve well-being in some individuals by promoting lean body mass and supporting healthy metabolic function. We conducted an open-label study to evaluate the efficacy of CF root extract for weight management. Methods After obtaining informed consent, 15 healthy volunteers participated in an 8-week open-label study. The subjects received 500 mg of CF extract (10% forskolin) twice a day with their meals. Body composition measurements were conducted using a bioelectric impedance analyzer once each week. Body weight (kg), fat content (kg), lean body mass (kg), and basal metabolic rate (kcal/day) were also measured and documented. Results Of the 15 subjects, 12 (mean age 32.2 ± 2.3 years) completed the study. Significant decreases compared with baseline were observed after 8 weeks for body mass index (BMI) (24.92 ± 0.87 to 23.99 ± 0.86 kg/m 2 , p = 0.0038), body weight (66.33 ± 3.00 to 63.96 ± 3.10 kg, p = 0.0038), fat content (29.64 ± 2.19 to 27.77 ± 2.27 kg, p = 0.0038), lean body mass (44.34 ± 2.98 to 43.93 ± 3.01 kg, p = 0.0044) and basal metabolic rate (1379.1 ± 74.4 to 1363.9 ± 77.5 kcal, p = 0.0254). Conclusion These findings suggest that CF root extract has potential as an adjunct therapy for the treatment of obesity. Further studies using double-blind, randomized, placebo-controlled designs are warranted to conclusively demonstrate the effectiveness of CF root extract in personalized supplements and/or pharmacological interventions. |
| Databáze: | OpenAIRE |
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