S1309 Gastrointestinal Manifestations in COVID-19 Patients in the United States

Autor:	Mohammad Bilal, Douglas K. Pleskow, Mandeep S. Sawhney, Joseph D. Feuerstein, Cinthana Kandasamy, Jack Mlabasati, Roya Dastjerdi, Jonah Cohen, Tyler M. Berzin
Rok vydání:	2020
Předmět:	medicine.medical_specialty Abdominal pain Hepatology Nausea business.industry media_common.quotation_subject Gastroenterology Rectum Appetite Disease Diarrhea medicine.anatomical_structure Melena Internal medicine medicine Vomiting medicine.symptom business media_common
Zdroj:	American Journal of Gastroenterology. 115:S657-S658
ISSN:	1572-0241 0002-9270
DOI:	10.14309/01.ajg.0000707284.36554.40
Popis:	INTRODUCTION: Although the typical presentation of COVID-19 infection includes fever and respiratory complaints, gastrointestinal (GI) symptoms are also common at the time of diagnosis Case-series mainly from eastern Asia have reported varying frequency of GI symptoms in COVID-19 patients Given the regional variations in manifestation of disease, we sought to analyze the prevalence and characterization of gastrointestinal symptoms in COVID-19 patients in the northeastern region of the United States METHODS: We identified and analyzed all patients who underwent COVID-19 testing at our institution between January and March of 2020 Those patients who were hospitalized and confirmed to have COVID-19 infection served as the cases Patients during the same time period who tested negative for COVID-19 served as controls Detailed information, including patient demographics, presenting complaints, diagnostic testing, hospital course, and outcomes, was collected We categorized GI symptoms to include nausea, vomiting, diarrhea, abdominal pain, red blood per rectum, melena, loss of appetite, and loss of taste RESULTS: Out of 307 hospitalized patients who were tested for COVID-19 at our institution, 139 patients tested positive for COVID-19 infection, and 131 patients tested negative for COVID-19 The remaining 37 patients were excluded due to inconclusive or incomplete results Diarrhea (25 2%, OR = 2 4) and loss of appetite (25 9%, OR = 3 2) were the most common GI symptoms in COVID-19 patients, and both were significantly more common when compared to the patients in the control group [Table 1] Other GI symptoms including nausea, vomiting, and abdominal pain were present in 10-20% of COVID-19 patients Isolated gastrointestinal symptoms without the presence of respiratory symptoms occurred in 7 2% of COVID-19 patients at time of diagnosis New-onset GI symptoms after admission were noted in 17 4% of COVID-19 patients There was no significant association between the presence of GI symptoms and disease severity CONCLUSION: Diarrhea and loss of appetite were the most common presenting GI symptoms in patients diagnosed with COVID-19 infection when compared to the control group About 7% of COVID-19 positive patients presented with isolated GI symptoms alone New-onset of GI symptoms developed during admission in 17% of COVID-19 patients The presence of GI symptoms does not appear to be an independent predictor of severe disease or the need for ICU admission
Databáze:	OpenAIRE
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